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KMID : 0371320080750060425
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Journal of the Korean Surgical Society
2008 Volume.75 No. 6 p.425 ~ p.429
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Central Diabetes Insipidus in Patients with Inhalation Injury
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Cho Yong-Suk
Kim Do-Hern
Hur Jun
Chun Wook
Kim Jong-Hyun
Yim Hae-Jun
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Abstract
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Central diabetes insipidus (DI) is caused by failure of ADH release from the posterior pituitary gland. Common causes of central DI in critically ill patients include traumatic brain injury, anoxic encephalopathy, meningitis, primary or metastatic brain tumor and brain death. Inhalation burn injury with thermal injury can cause profound brain damage according to the degree of gas inhalation. This results in pituitary failure with diabetes insipidus (DI) and secondary adrenal insufficiency. We recently experienced 3 cases of central diabetes insipidus with inhalation burn injury, aggravated polyuria and abnormal serum or urine osmolarity. Severe burn injury is not easy to treat in and of itself, moreover, if central diabetes insipidus is combined it is difficult to manage appropriately. Therefore, if we suspected central diabetes insipidus, early aggressive control would lower mortality and morbidity. We report therapeutic experience in these cases with a review of the literature. (J Korean Surg Soc 2008;75:425-429)
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KEYWORD
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Central diabetes inspidus, Inhalation burn injury, Osmolarity
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